
Mobility
ALRIGH2T
ALRIGH2T aims to facilitate the transition to climate-neutral propulsion systems based on liquid hydrogen (LH2) by developing two pioneering ground-based...
Biogenic Organotropic Wetsuits: self-contained implantable materials and devices
Project dates
2020 - 2024
Website
Role of Zabala
partner
Project led by
CSGI - Consorzio per lo Sviluppo dei sistemi a Grande Interfase
11
Partners
7
Countries
4.5
M€ budget
4
Years
The objective of the project is to explore and consolidate a technology capable of endowing the capabilities of extracellular vesicles (EVs) to superparamagnetic nanodevices by “dressing” them with a “suit” of one or more layers of EV membrane “fabric.”
Until a few years ago, cell communication was thought to be regulated exclusively through cell-cell junctions or by the exchange of soluble molecular factors. However, it has been discovered that membranous nanoparticles, called extracellular nanovesicles (EVs), and tunneling nanotubes are also intercellular communication agents “made by cells for cells.” Their function is to transport lipids, proteins and nucleic acids, and they stand out for their precision and targeting ability, carried out thanks to the unique composition and structure of their membrane (which to date is inaccessible to synthetic mimics).
The BOW project will develop a technology capable of endowing the capabilities of extracellular vesicles (EVs) to superparamagnetic nanodevices (Magnetic Bead Devices, MBDs) by “dressing” them with a “suit” of one or several layers of EV membrane “fabric.” It will establish a general and viable paradigm for applying key biomimetic functions – including the ability to evade the immune system and reach target organs/tissues/tumors – to any synthetic nanodevice. In turn, it will be disruptive in that it will be the first example of biogenic nanotechnology.
This technology will promote the progress of implantable nanodevices and nanomaterials towards sustainable production and the clinic, impacting people’s quality of life. The main objectives include: i) production of EVs with biomimetic and organotropic functions, ii) synthesis and functionalisation of MBDs, iii) engineering of a microfluidic device for optimised fabrication of membrane-coated MBD EVs, iv) evaluation of biological performance and nanotoxicity of evMBDs and in-vitro, ex-vivo and in-vivo.
This project has received funding from the European Union’s FET Proactive programme, under grant agreement No. 952183.
“The BOW project will develop and demonstrate an innovative technology based on extracellular vesicles and paragenetic nanodevices with applications in various fields related to human health (clinical, environmental and food safety). BOW is a clear example of science at the service of society.”
Blanca Rodríguez
Team leader with expertise in European Programmes
The European BOW Project concludes with promising results and strong partnerships
Mobility
ALRIGH2T aims to facilitate the transition to climate-neutral propulsion systems based on liquid hydrogen (LH2) by developing two pioneering ground-based...
Energy
HELENA responds to the need of the development of a safe, novel high energy efficiency and power density solid state...
Agroalimentation and bioeconomy
PROBIO seeks to support the Bioeconomy sector to exploit its R&D results and facilitate their transfer to the market.
News
BRIDGE
Zabala Innovation lead the coordination of the fifth BRIDGE General Assembly – the key annual conference of the European Commission initiative that unites energy-related projects in the area of Smart Grid, Energy Storage, Islands and Digitalisation to create a structured view of cross-cutting issues.
Opinion
European projects
Rocío Fernández
EU Finance Knowledge Area Leader
Publication
10th Framework Programme
Explore the document in which we share our recommendations and strategic vision for the forthcoming 10th Framework Programme
The important thing is not to keep moving, but rather to know in which direction to go. Our 37% success rate proves that we know how to guide our clients.
Our compass is our clients; our mission is to solve their problems, guiding them so that innovation becomes their key to competitiveness.